Sunday, March 23, 2014

Assignment 7, Video 2: USPTO Guidelines on Determining Obviousness


Assignment 7, Blog Post 2: USPTO Guidelines on Determining Obviousness

Since this week's assignment was to talk about obviousness, I wanted to go over some of USPTO's guidelines for determining obviousness.  As Professor Lavian mentioned in class, some law schools, such as Stanford, have an entire course on obviousness! In 2010, USPTO released a set of updated guidelines on determining obviousness. In link [1] below, you can find a table from the Federal Register that talks about "Combining Prior Art Elements", "Substituting One Known Element for Another", "The Obvious to Try Rationale",  and "Consideration of Evidence".

Here, I will briefly summarize some of the facts that I learned:

-- Even when there exists a general method to make the claimed product and this method can be used by an ordinary artisan, the claim is still nonobvious if the suggested use of the method had not been known before.

-- The claimed invention is likely to be obvious if the inventor combines elements from prior art that would reasonably have been expected to maintain their respective properties or functions after they have been combined. While this may seem self-evident, I think it is good to state explicitly.  Here, the question that arises is how one would define reasonable.

-- "When determining whether a reference to a different field of endeavor may be used to support a case of obviousness (i.e. is analogous), it is necessary to consider the problem to be solved." The professor talked about this in class as well: For example, a processor can refer to a processor in a laptop or electronic device or it could refer to a food processor. (this was the example given in class). So when is it appropriate to link these two completely separate fields and when is it not appropriate to do so? Here, USPTO is saying that we need to consider the problem being solved when making the connection. Another related guideline is: "Analogous art is not limited to references in the field of endeavor of the invention, but also includes references that would have been recognized by those of ordinary skill in the art as useful for applicant's purpose".

When it comes to learning more about obviousness, I think these tables are a good place to start-- so definitely take a look at them!


Assignment 7, Video 1: Narrow Range versus Broader Range


Assignment 7, Blog Post 1: Narrow Range versus Broader Range

For this week's blog posts, the theme is obviousness. I wanted to discuss an article from Patentlyo.com titled, "Whither Obviousness: Narrow Range Anticipated by Broader Range in Disclosure" by Dennis Crouch. Consider an  invention "that is anticipated, but likely not obvious. According to the apellate panel, the prior artfully discloses and enables the invention but also teaches that the proposed invention is impractical and does not work well." [1] This is part of a classic hypothetical case presented in law schools.

The patent that we are considering is given in link [2] below. This patent protects a process for clarifying water using a flocculated suspension of aluminum and quarternized polymers. The patent owner and inventor, Richard Haase, has filed more than 50 patents on water purification/ energy and is the CEO of ClearValue. Pearl River, who was once a customer of ClearValue, later began making its own patented  process. Haase sued them for patent infringement and for trade secret violation. The conclusion is that "a broad range disclosure found in the prior art ("less than 150 ppm") anticipates the narrower range found in the claims ("less than 50 ppm"). Under 35 U.S.C. § 102, "a claim will be anticipated and therefore invalid if a single prior art reference describes 'each and every claim limitation and enable[s] one of skill in the art to practice an embodiment of the claimed invention without undue experimentation'"[1]

The Federal Circuit addressed a similar situation in the 2006 Atofina decision, in which there was a narrow claimed temperature range and the prior art dictated a broader temperature range. At that time, the final decision was that the broad range disclosed in the prior art did not anticipate the narrow range claimed later. Instead, it was agreed that there was something significant about the claimed temperature range. However, in this case, the court ruled that "the narrow range is not critically different from the broad range….[and] that the claimed narrow range was fully disclosed by the broad range and therefore is unpatentable."[1]

Okay, so how does all this relate to obviousness? The article states:

"The mechanism that the court used to distinguish this case from Atofina is very much akin to obviousness principles-- looking essentially for synergy or unexpected results that make the narrow range qualitatively different from the broad range" [1]

Take a look at the article and actual patent if you are interested in learning more about the case!  (see links below)


Friday, March 7, 2014

Assignment 6, Video 2: Bioprinting Patents


Assignment 6, Blog Post 2: Bioprinting Patents

So, my last blog post was on 3D printing technology in general, and I somewhat focused on the stereolithography part since some of those patents were expiring very soon-- in the next five days!   I wanted to stick to a similar topic for my second blog post this week, and wanted to talk about 3-D printing in tissue engineering applications. Usually, there are many arguments with patents that are in the health and biology area (such as patents on genetic sequences), because it is important to differentiate the human innovation versus something made by nature.

The article I read is titled, "A Look at The Patentability of 3-D Printed Human Organs". Bioprinting is the intersection of 3D printing and inkjet printing to print layers of living cells. Multiple layers of cells are stacked within a gel-based material to form functional living tissue. As a bioengineer, I think this is really interesting and exciting area. As of today, scientists have already created functional 3D human blood vessels and mini-livers using this technology. There is also the potential to generate entire human-sized living organs (although there are some scientific challenges to overcome that I won't get into here-- but feel free to ask me in person!).

In class, we all have learned that patent protection is extremely important, for it allows inventors to fully capitalize on their investment, by discouraging or delaying competition. In this blog, I wanted to focus on some issues related to patenting artificially created living human tissue.  The patent office and Congress rule that patens on human organisms are not eligible for patent protection. However, according to the article, inventors have successfully been able to "obtain protection for genetically engineered animals by narrowing the claim scope to 'nonhuman' subjects" [1].  One example of this is U.S. Patent No. 8,088,968, which claims:
"a 'non-human mammal' with a particular genome composition where the nonhuman mammal is a mouse. A 'tissue' of such nonhuman mammal is also separately claimed."
Also, it is important to note, that while the above is deemed patentable, the USPTO has rejected patent claims on a human embryo under 35 U.S.C. Section 101 and also because it violates Section 33(a) of the Leahy-Smith America Invents Act.

Back to bioprinting human organs. The previous argument was for patenting animals other than humans. What are some arguments in favor of patents for bioprinted organs?
"Rather than viewed as products of nature, bioprinted organs and tissue may be considered to be manmade living materials artificially arranged in accordance with a particular printing geometry that facilitates any naturally occurring cell behavior"[1].
One similar example is U.S. Patent No. 8,394,141, which includes claims directed to an implant created from "fibers of defatted, shredded, allogeneic human tissue" such as "tendon, fascia, ligament, or dermis" and further including a "growth factor" (which helps in the differentiation of cells to the desired cell type). Allogenic tissue is basically tissue not from the same individual (which would be autologous), but from the same species. Thus, if patents on tissue-
engineered implants are allowed, so should patents on bioprinted organs.

So, what do you guys think? Do you think patents on bioprinted organs should be allowed or not? Please respond in the comments below!


Assignment 6, Video 1: Patents in 3-D Printing


Thursday, March 6, 2014

Assignment 6, Blog Post 1: Patents in 3D Printing


This topic was actually brought up (quite randomly actually!) by a friend of mine recently. He works at the machine shop at UC Berkeley, and he mentioned how in 2009, the patent on the 3D printer expired and how everyone started delving into that market, since it was so lucrative. Soon after, smaller desktop 3D printers came out. Thus, I decided to look into it.

According to an article written by John Hornick and Dan Roland on a few months ago, 3D printing is a 30 year technology that has recently starting entering the mainstream, but has not yet become commonplace. Hornick and Roland questioned what is holding this industry back? Some people argue that patents have held back innovation in 3D printing technology, because the companies are worried about getting sued, so they do not spend the resources to develop the technology. This in turn, reduces competition, keeping prices high and creating barriers to discourage others from entering the market. Other people argue that this is not actually the case, and what is holding 3D printers from becoming more commonplace is that the printers are too slow and cumbersome. "Regardless of where one stands in this debate, the threat of a lawsuit is certainly real and the 3D Printing Patent Wars, like Smart Phones Wars, are probably not too far down the pike." [1]

Link 1 below is a very good website to go to for a summary on the key 3D printing patents. Some of them have expired last year or beginning of 2014, but there are still many more that are expiring this month, as well as the next coming months (as well as some in 2015). I just wanted to spend some time talking about the patents that will expire soon and how this will affect the 3D printing industry in general.

There are several patents that are expiring in just the next few days (on March 11th):

Patent 5,609,812 is titled, "Method of Making a Three-Dimensional Object by Stereolithography". This is for making a 3D object from a medium that will soilidify after exposure to synergistic stimulation, such as ultra violet or infared radiation. While stereolithography is a very common invention, this method improves on it by allowing to identify an endpoint of the first vector and the beginning of the second vector (the vectors define the pattern of exposure). The invention also comprises a method for scanning at a fixed velocity along the first vector and mechanically blocking the UV or IR.

Patent 5,609,813 is also titled "Method of Making a Three-Dimensional Object by Stereolithography." This goes back to what we discussed in class this week on how  mulitple patents can have the same name. However, since patents talk about innovation, their claims must be different. This patent protects a method of applying a layer or flowable material, generating and sequencing the pattern of exposure paths for the layer, and exposing these paths to the UV/IR radiation according to the sequence. To me, this sounded really broad at first, but I'm sure there are more details that can easily be discerned by someone who is knowledgeable in the area.

Patent 5,610,824 is titled, "Rapid and Accurate Production of Stereolithographic Parts".  This patent protects an apparatus and a method for the same type of process talked about in the first two patents. We also discussed in class what can be patented (basically anything made by man). While the previous two patents protected methods (or processes), this patent protects both a product (a container with the medium) and a method (generating a beam of radiation). Here, what is different is that the beam of radiation has different first and second intensities and thus the two lines are scanned at different intensities. This is useful for large and complex objects, because the laser can be directed over portions of the material without curing a significant amount. 

A patent that I am interested in is expiring June 2nd of this year. This patent (No. 5,503,785)  protects a process for producing 3D objects having overhanging fragments freely suspended in space. I believe that once this patent expires, many others will come into the market, since it is a huge space.

The article concluded by saying that it is unknown "when the major battles of the 3D Printing Patent Wars will begin. New laws, evolving technology, and an unpredictable economy might affect 3D printing more than any of these patents. Thus, if would be imprudent to say that the expiration of one or more of them is the key to growth because the market can dictate otherwise."[1]



Saturday, March 1, 2014

Assignment 5, Video 2: Patent War in Pharmaceutical Industry


Assignment 5, Blog Post 2: Patent War in Pharmaceutical Industry

Since I find the patent wars in the pharmaceutical industry particularly interesting, I decided to focus on that topic this week. I find patents on drugs interesting due to the huge amount of funding and time needed to even get a drug into market. According to forbes.com, the average cost of bringing a new drug to market is $1.3 billion. To put this price in perspective, 1.3 billion dollars would allow a person to buy 371 Super Bowl ads, 16 million official NFL footballs, two pro-football stadiums, almost all NFL football player's salaries, and every seat in the NFL stadium for six weeks in a row.  The drug developed by major pharmaceutical companies costs between $4 billion to $ 11 billion.[2]

This is an example of patent war with another popular company in the Bay Area-- Bayer, which has a manufacturing center located in Emeryville (although its headquarters is in Germany). Bayer was battling Pharma Dynamics, a Cape Town- based generic drug maker. I learned that Bayer is called the "evergreening" of pharmaceutical patents, meaning that they make small changes to existing products in order to extend their patent protection and keep makers of cheaper generics out of the market.

On March 2011, Pharma Dynamics obtained registration from Medicines Control Council (MCC) for Ruby, a contraceptive drug. Ruby was a generic version of Yasmin, a drug that was still under patent protection by Bayer. Pharma Dynamics believed that the Yasmin patent, which was granted in 2004, was invalid and applied to revoke the patent, after obtaining approval from the Medicines Control Council (MCC) to sell Ruby. The company claimed that "the Yasmin patent lacked 'novelty' and 'inventiveness' because Bayer had already patented the product in 1990." This would mean that the patent expired in 2010, since the standard practice, followed internationally, calls for 20-year protection. This 20-year period is set to allow the inventor to compensate for their investment and make a profit before other competitors can copy them. The business development director of Pharma Dynamics', Tommy Scott, said that the company waited for the Yasmin patent to expire, and wasn't aware of the second patent issued in 1999. Bayer claimed that this patent was original, because it contained an active ingredient that allowed the drug to dissolve faster.

It seems that there have been growing patent disputes in many developing countries, as companies try to bring down the cost of medicine by promoting generic versions, normally termed "incremental innovation" by research-based companies. Competitors argue that by doing this (filing several patents on discoveries made years ago), the original inventors limit competition.




Assignment 5, Video 1: Patent War in Pharmaceutical Industry


Assignment 5, Blog Post 1: Patent War in Pharmaceutical Industry

Genzyme Corporation is a company based in Cambridge Massachusetts, and Genentech (which many of you probably have heard about) is headquartered right here in the bay area in South San Francisco. These two companies filed lawsuits against each other over a clot-breaking agent for heart attack patients.

Genzyme had a 1994 patent for a chemical produced through genetic engineering of DNA. The company claimed that Genentech's TNKase "clot-busting" product infringed this patent. This dispute was  mainly focused on "whether payments were due under a license Genzyme had granted to Genentech" according to William Marsden Jr., the Genzyme lawyer.

Genentech then sued back in 2001, asserting that the technology they use is different, hoping that the court would rule that the patent didn't cover the product or that the patent was invalid.

Here is another similar case with a different drug (t-PA) that I found even more interesting: Toboyo is a four billion dollar textile and pharmaceutical maker, which is involved in making the t-PA drug, under license from Genzyme. In late 1991, Osaka District court bailiffs decided to confiscate the drug at the Toyobo plant in Japan, because Toyobo's sale infringed Genentech's Japanese patent. What I find extremely interesting about this case, especially from a patent's perspective, is that "Royalties from the drug's sales in Japan were not expected to make major contributions to revenues at either Genentech or Genzyme, but the case was called significant because of its implications for patents in Japan…[for] the case was the first seizure of a product by Japanese authorities to protect a biotechnology patent".  G Kirk Raab, the Chief executive of Genentech, said that "It's a strong affirmation on the part of Japan's judicial system. It says to the biotech industry that strong patents will be supported by Japanese courts". Unfortunately, this decision was bad news for Toboyo, because t-PA was one of Toboyo's first major pharmaceutical and the company had invested in establishing production processes and marketing scheme for t-PA.